Food Grade Vitamin B3 - Essential Niacin for Health Supplement Formulations
Introduction to Niacin Technology
Vitamin B3 (Niacin) represents a critical component of human metabolism, existing in two primary forms - nicotinic acid and nicotinamide. Our food-grade niacin meets stringent international standards, offering manufacturers a versatile nutrient powder with exceptional stability and bioavailability. This high-purity ingredient serves as the precursor for NAD/NADP coenzymes involved in over 400 biochemical reactions, making it indispensable for addressing pellagra prevention, cardiovascular health, and energy metabolism support in modern nutritional formulations.
Key Product Specifications
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Available Forms: Nicotinic Acid & Nicotinamide
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Purity: ≥99.5% (USP/FCC/EP standards)
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Appearance: White crystalline powder
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Solubility:
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Nicotinic acid: 1.6g/100mL (water)
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Nicotinamide: 100g/100mL (water)
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Thermal Stability: Stable up to 150°C (302°F)
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Certifications: FCC, USP, EP, FDA 21CFR184.1530 GRAS
Biochemical Functions & Clinical Benefits
1. Energy Metabolism
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Essential for glycolysis and Krebs cycle
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NAD-dependent dehydrogenase reactions
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Supports mitochondrial ATP production
2. Cardiovascular Support
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Nicotinic acid modulates lipid profiles:
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Reduces LDL (10-20%)
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Increases HDL (15-35%)
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Lowers triglycerides (20-50%)
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3. Cellular Repair & Maintenance
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PARP-mediated DNA repair
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Sirtuin activation for cellular longevity
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Keratinocyte differentiation support
4. Specialized Applications
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Pellagra prevention/treatment
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Type 1 diabetes support
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Neuroprotective effects
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Skin barrier enhancement
Target Populations for Supplementation
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Cardiovascular Patients: Lipid management
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Aging Population: NAD+ replenishment
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Alcohol-dependent: Increased requirements
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Vegetarians: Limited tryptophan conversion
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Pregnancy: Fetal development needs
Supplement & Fortification Applications
1. Nutritional Supplements
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B-complex formulations (20-500mg)
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Cardiovascular support products
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Energy metabolism blends
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Anti-aging NAD+ boosters
2. Food Fortification
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Enriched flour (24mg/lb)
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Breakfast cereals
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Sports nutrition products
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Clinical nutrition formulas
3. Pharmaceutical Preparations
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Extended-release niacin therapies
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Pellagra treatment regimens
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Topical acne formulations (nicotinamide)
Technical Advantages for Manufacturers
1. Enhanced Stability Profile
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Resists oxidation and hydrolysis
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Maintains potency in multivitamin blends
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Withstands high-temperature processing
2. Bioavailability Optimization
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Rapid gastrointestinal absorption
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Efficient conversion to NAD/NADP
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Tissue-specific utilization
3. Formulation Flexibility
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Direct compression compatible
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Soluble forms for liquid products
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Microencapsulation options available
Quality & Safety Assurance
Global Regulatory Status
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FDA: GRAS (21CFR184.1530)
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EU: Approved food additive (E375)
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Codex: Included in NRVs
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JECFA: ADI not specified (nicotinamide)
Safety Considerations
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Flushing response (nicotinic acid)
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Upper limit: 35mg/day nicotinic acid
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Hepatotoxicity monitoring at therapeutic doses
Quality Control Protocol
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HPLC purity verification
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Heavy metals <10ppm
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Residual solvents per ICH guidelines
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Microbiological standards compliance
Usage Guidelines
Recommended Daily Intakes
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Adults: 14-16mg NE
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Pregnancy: 18mg NE
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Therapeutic doses: 50-2000mg
Formulation Best Practices
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Dry Blending: Uniform distribution
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Flush-free Formulations: Inositol hexanicotinate
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pH Adjustment: For improved solubility
Stability Considerations
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Protect from excessive moisture
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Avoid strong oxidizing agents
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Nicotinamide more stable in liquids
Why Choose Our Niacin?
1. Scientific Validation
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Batch-specific certification
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Stability studies available
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Clinical efficacy data
2. Technical Support
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Flushing mitigation strategies
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Solubility enhancement
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Regulatory documentation
3. Supply Chain Excellence
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cGMP manufacturing
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Multiple packaging options
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Global distribution network
Market Trends & Innovations
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Longevity Science: NAD+ boosting formulations
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Cardiovascular Health: Non-flushing technologies
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Sports Nutrition: Energy metabolism optimization
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Beauty Supplements: Skin health applications
Sustainability Features
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Eco-friendly synthesis
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Reduced packaging waste
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Energy-efficient production
| PSA | 55.98 |
| XLogP3 | 0.8808 |
| Appearance | Nicotinamide is a white powder. (NTP, 1992) |
| Density | 1.400 g/cm3 @ Temp: 25 °C |
| Melting Point | 130 °C |
| Boiling Point | 157 ðC @ Press: 5 x 10-4àTorr |
| Flash Point | 182°C |
| Refractive Index | 1.4660 (estimate) |
| Water Solubility | 1000 g/L (20ºC) |
| Vapor Pressure | Vapour pressure, kPa at 35°C: 3.1 |
| Vapor Density | Relative vapour density (air = 1): 4.2 |
| Toxicity | LD50 s.c. in rats: 1.68 g/kg (Brazda, Coulson) |
| Odor | Odorless |
| Taste | Bitter taste |
| PH | 10% "wt in vol" solution in water is neutral to litmus |
| PKA | 3.35(at 20 °C) |
Use:
1. Niacinamide USP is used as food additive, for multivitamin preparations and as intermediate for pharmaceuticals and cosmetics. WWW Link
2. Niacinamide USP DC is used as food additive, for multivitamin preparations and as intermediate for pharmaceuticals WWW Link
3. A water-soluble vitamin B, incorporated within nicotinamide cofactors such as NADH and NADPH.
4. Vitamin B3; enzyme cofactor; anti-pellagra
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About Beijing TDD E-commerce Co., Ltd.
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