High-Quality Folic Acid Vitamin B9 Food Grade - Pure Folic Acid for Health Products

Introduction to Folic Acid Science

Folic acid (pteroylmonoglutamic acid) represents the most stable and bioavailable form of folate for nutritional fortification. Our food-grade folic acid meets stringent pharmacopeial standards, offering manufacturers a bright yellow crystalline powder with exceptional purity and consistent performance. As a critical methyl donor and nucleotide synthesis cofactor, this essential B vitamin plays fundamental roles in cell division, neural development, and epigenetic regulation, making it indispensable for prenatal health, cardiovascular protection, and comprehensive wellness formulations.

Key Product Specifications

• Chemical Name: Pteroyl-L-glutamic acid

• Molecular Formula: C₁₉H₁₉N₇O₆

• Purity: ≥97% (USP/FCC/EP standards)

• Appearance: Yellow to orange-yellow crystalline powder

• Solubility: 0.0016g/L in water (improves with pH adjustment)

• Thermal Stability: Stable up to 100°C (212°F)

• Certifications: FCC, USP, EP, FDA 21CFR172.345 GRAS

Biochemical Functions & Clinical Significance

1. Cellular Proliferation Support

• DNA/RNA synthesis cofactor

• Thymidylate production

• Purine biosynthesis

• Rapidly dividing cell support

2. Methylation Cycle Regulation

• Homocysteine conversion to methionine

• Epigenetic DNA methylation

• Neurotransmitter synthesis

• Histone modification

3. Developmental Applications

• Neural tube closure (400-800μg/day)

• Fetal organogenesis

• Placental development

• Childhood growth

4. Specialized Health Benefits

• Cardiovascular protection

• Cognitive function maintenance

• Mood regulation

• Chemotherapy adjunct

Target Populations for Supplementation

• Preconception/Pregnancy: 400-800μg daily

• MTHFR Polymorphism: Impaired conversion

• Elderly: Absorption decline

• Cardiovascular Patients: Homocysteine control

• Alcohol-dependent: Increased excretion

Supplement & Fortification Applications

1. Nutritional Supplements

• Prenatal formulations (400-1000μg)

• B-complex products

• Cardiovascular health blends

• Senior multivitamins

2. Food Fortification

• Enriched flour (140μg/100g)

• Breakfast cereals

• Infant formulas

• Meal replacement products

3. Clinical Nutrition

• Therapeutic repletion protocols

• Oncology support

• Malabsorption syndromes

• Hematologic disorders

Technical Advantages for Manufacturers

1. Enhanced Stability Profile

• Superior to reduced folate forms

• Maintains potency in multivitamin blends

• Withstands standard food processing

2. Bioavailability Optimization

• Efficient dihydrofolate reductase conversion

• Standardized absorption kinetics

• Predictable serum response

3. Formulation Versatility

• Microencapsulation options

• Compatible with direct compression

• Stable in pH 4-8 systems

Quality & Safety Assurance

Global Regulatory Status

• FDA: GRAS (21CFR172.345)

• EU: Approved food additive

• WHO: Mandatory fortification guidelines

• Codex: Included in NRVs

Safety Considerations

• UL established at 1000μg (synthetic)

• Masking B12 deficiency risk

• Drug interaction monitoring

Quality Control Protocol

• HPLC purity verification

• Heavy metals <10ppm

• Residual solvent analysis

• Microbiological standards compliance

Usage Guidelines

Recommended Daily Intakes

• Adults: 400μg DFE

• Pregnancy: 600μg DFE

• Lactation: 500μg DFE

• Therapeutic doses: 1-5mg

Formulation Best Practices

1. Dry Blending: Uniform distribution

2. Liquid Systems: Solubilizer required

3. Protection: From light and moisture

Stability Considerations

• Amber glass/opaque packaging

• Storage below 25°C (77°F)

• Avoid reducing agents

Why Choose Our Folic Acid?

1. Scientific Validation

• Batch-specific certification

• Photostability studies

• Bioequivalence data

2. Technical Support

• Stability testing protocols

• Bioavailability enhancement

• Regulatory documentation

3. Supply Chain Excellence

• cGMP manufacturing

• Light-protected packaging

• Global distribution network

Market Trends & Innovations

• Prenatal Nutrition: Neural protection

• Precision Nutrition: MTHFR targeting

• Healthy Aging: Methylation support

• Clean Label: Fermentation-derived options

Sustainability Features

• Eco-friendly synthesis

• Reduced packaging waste

• Energy-efficient production

SA	213.28
XLogP3	-1.1
Appearance	Folic acid appears as odorless orange-yellow needles or platelets. Darkens and chars from approximately 482°F.
Density	1.68 g/cm3
Melting Point	250 °C (decomp)
Refractive Index	1.755
Water Solubility	H2O: 1.6 mg/L (25 ºC)
Storage Conditions	2-8ºC
Vapor Pressure	6.2X10-20 mm Hg at 25 deg C /Estimated/
Specific rotation	Specific optical rotation: +23 deg at 25 °C/D (c= 0.5 in 0.1 N sodium hyroxide)
Odor	Odorless or almost odorless
Taste	Tasteless
PH	A suspension of 1 g of folic acid in 10 ml of water has a pH of 4.0-4.8. Aq solutions prepared with sodium bicarbonate have a pH between 6.5 and 6.8.

 

Use:

Medication. Biochemical research; clinical drugs are vitamin B family, used for the treatment of pregnancy and infantile giant cell anemia. Anti-anemia drugs for symptomatic or nutritional giant cell anemia. Used as a biochemical reagent, also used in the pharmaceutical industry and other purposes. Folic acid is an anti-anemia drug. When livestock and poultry lack folic acid, appetite decreases, growth is blocked, and feathers grow poorly. The dosage is 0.5-1.0mg/kg. As a food fortifier. It can be used in foods for infants and young children with a dosage of 380-700μg/mg; in special foods for pregnant women and nursing mothers, the dosage is 2 to 4mg/kg. Anti-anemia drugs; can also prevent most neural tube defects (NTDs).

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