VB12 Vitamin B12 Cyanocobalamin - Essential Vitamin for Health Supplements

Introduction to Vitamin B12

Vitamin B12 (Cyanocobalamin) is a critical water-soluble vitamin that plays fundamental roles in red blood cell formation, neurological function, DNA synthesis, and energy metabolism. Our pharmaceutical-grade Cyanocobalamin powder meets stringent USP/EP standards, offering manufacturers a stable, bioavailable form of this essential nutrient for dietary supplements, functional foods, and clinical nutrition products. With increasing global awareness of B12 deficiency risks—particularly among vegetarians, elderly populations, and individuals with absorption disorders—this high-purity ingredient has become indispensable for preventive healthcare formulations.

Key Product Specifications

• Chemical Name: Cyanocobalamin (Cobalamin)

• Purity: ≥98% by HPLC

• Appearance: Dark red crystalline powder

• Solubility: 1.25g/100mL in water (slightly soluble in ethanol)

• Stability: 24 months when stored below 25°C (protected from light/moisture)

• Certifications: USP/EP, FCC, Kosher, Halal, ISO 9001 certified

Biological Functions & Health Benefits

Vitamin B12 acts as a coenzyme in two crucial metabolic pathways:

1. Hematopoietic Support

• Essential for erythrocyte (red blood cell) production

• Prevents megaloblastic anemia

• Works synergistically with folate (B9)

2. Neurological Maintenance

• Required for myelin sheath formation

• Supports cognitive function

• May help prevent peripheral neuropathy

3. Energy Metabolism

• Facilitates conversion of food to cellular energy (ATP)

• Reduces fatigue and weakness

4. Other Critical Roles

• DNA/RNA synthesis

• Homocysteine regulation (cardiovascular protection)

• Methylation cycle support

Target Populations for Supplementation

• Vegans/Vegetarians: Absent in plant-based diets

• Older Adults: 10-30% over 50 have absorption issues

• Pernicious Anemia Patients: Autoimmune condition affecting intrinsic factor

• Gastrointestinal Disorders: Crohn's, celiac disease, gastric bypass patients

• Chronic Medication Users: Metformin, PPIs reduce absorption

Supplement & Fortification Applications

1. Dietary Supplements

• Tablets/Capsules: 50–1000 mcg doses

• Sublingual Forms: Enhanced absorption

• Multivitamins: B-complex formulations

• Injectable Solutions: Medical/therapeutic use

2. Functional Foods

• Fortified Cereals: 25% DV per serving

• Plant-Based Milks: Almond/soy milk enrichment

• Energy Bars: 1–5 mcg/g addition

• Nutritional Yeast: Vegan B12 source

3. Clinical Nutrition

• Enteral/Parenteral Feeds

• Geriatric Nutrition Products

• Sports Nutrition Formulas

Technical Advantages for Manufacturers

1. Superior Stability

• More stable than methylcobalamin

• Withstands tableting pressures

• Maintains potency in multivitamin blends

2. Enhanced Bioavailability

• Converts efficiently to active coenzymes

• Standardized dissolution profile

3. Formulation Flexibility

• Compatible with most excipients

• Microencapsulation options available

• Suitable for vegan/vegetarian products

Quality & Safety Assurance

Regulatory Status:

• FDA: 21CFR184.1945 (GRAS)

• EFSA: Approved nutrient (EU 1925/2006)

• Codex Alimentarius: Included in nutrient reference values

Safety Profile:

• No established upper limit (excess excreted)

• Non-toxic at recommended doses

• 70+ years of clinical use history

Quality Control:

• Identity confirmed by UV-Vis spectroscopy

• Heavy metals <10 ppm

• Microbial limits per USP <61>

Usage Guidelines

Recommended Daily Intakes:

• Adults: 2.4 mcg (higher for pregnancy/elderly)

• Supplement Doses: 50–1000 mcg (accounts for absorption variability)

Formulation Tips:

1. Direct Compression: Blend with mannitol/microcrystalline cellulose

2. Liquid Formulas: Pre-dissolve in water with mild heating

3. Food Fortification: Uniform dispersion in dry blends

Stability Considerations:

• Protect from light/oxidizing agents

• Avoid excessive heat (>40°C)

• Incompatible with strong acids/bases

Why Choose Our Cyanocobalamin?

1. Scientific Validation

• Batch-specific certificate of analysis

• Third-party assay verification

• Stability studies available

2. Manufacturing Support

• Technical documentation packages

• Regulatory compliance assistance

• Custom particle size options

3. Supply Chain Reliability

• Global distribution network

• Multiple packaging formats

• Cold chain management

Market Trends & Innovations

• Vegan Nutrition Boom: 500% growth in plant-based B12 demand

• Personalized Nutrition: Age/specific-formulations

• Novel Delivery Systems: Liposomal, nanoemulsion technologies

Sustainability:

• Fermentation-derived production

• Eco-friendly packaging options

Usage and manufacturing

1. Vitamin, coenzyme B12
2. Prototype of the family of naturally occurring cobalt coordination compounds knows as corrinoids. Analogs of vitamin B12 which differ only in the σ-ligand of the cobalt are termed cobalamins. Synthesized almost exclusively by bacteria. Dietary sources include fish, meat, liver, and dairy products; plants have little or no cobalamins. Converted by the body into its bioactive forms, methylcobalamin and cobamamide, which serve as enzyme cofactors. Severe deficiency may result in megaloblastic anemia and/or neurological impairment.
3. A coenzyme for synthesis of nucleic acids and metabolism carbohydrates.

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